9
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11435 | GlyT1 Inhibitor 1 | Others | |
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor (IC50: 38 nM for rGlyT1) with antipsychotic activity. | |||
T37089 | Iclepertin | ||
Iclepertin (BI-425809) is a highly effective, selective, and orally bioavailable inhibitor of glycine transporter 1 (GlyT1). It exhibits no activity against GlyT2. Consequently, Iclepertin holds promise for advancing res... | |||
T6788 | Bitopertin | Paliflutine,RO4917838,RG1678 | GlyT |
Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells. | |||
T90597 | SSR504734 HCl | ||
SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 ( IC 50 =18, 15, and 38 nM, respectively). SSR504734 exhibits activity in schizophrenia, anxiety and depression models [1]. | |||
T61564 | PF-03463275 | PF-3463275 | GlyT |
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive defici... | |||
T22945 | LY 2365109 hydrochloride | Others | |
glycine transporter 1 (GlyT1) inhibitor | |||
T28858 | SSR504734 | SSR-504734,SSR 504734 | |
SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor. | |||
T16292 | NFPS | Thrombin | |
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM a... | |||
T37699 | Org 24598 | ||
Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transport... |