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Search Results for " glyt1 inhibitor 1 "

9

Compounds

Cat No. Product Name Synonyms Targets
T11435 GlyT1 Inhibitor 1 Others
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor (IC50: 38 nM for rGlyT1) with antipsychotic activity.
T37089 Iclepertin
Iclepertin (BI-425809) is a highly effective, selective, and orally bioavailable inhibitor of glycine transporter 1 (GlyT1). It exhibits no activity against GlyT2. Consequently, Iclepertin holds promise for advancing res...
T6788 Bitopertin Paliflutine,RO4917838,RG1678 GlyT
Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.
T90597 SSR504734 HCl
SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 ( IC 50 =18, 15, and 38 nM, respectively). SSR504734 exhibits activity in schizophrenia, anxiety and depression models [1].
T61564 PF-03463275 PF-3463275 GlyT
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive defici...
T22945 LY 2365109 hydrochloride Others
glycine transporter 1 (GlyT1) inhibitor
T28858 SSR504734 SSR-504734,SSR 504734
SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor.
T16292 NFPS Thrombin
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM a...
T37699 Org 24598
Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transport...
TargetMol